Premium
Mechanism of Sensitization to UV Radiation by 5‐Br‐Uracil Substituted DNA
Author(s) -
Lion M.
Publication year - 1972
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197200121
Subject(s) - chemistry , thymine , uracil , dna , sensitization , pyrimidine dimer , photochemistry , base pair , ultraviolet radiation , ultraviolet , biophysics , stereochemistry , dna damage , biochemistry , radiochemistry , optoelectronics , physics , immunology , biology
DNA, in which thymine is substituted by 5‐bromouracil is sensitized to the effect of ultraviolet light. Various chemical changes produced in the DNA are described. These include single and double strand breaks, base loss, protein DNA crosslinks as well as the influence of the three dimensional structure of DNA on some of these changes.