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Polydepsipeptides I. Synthesis and Characterization of Copolymers of α‐Amino and α‐Hydroxy Acids
Author(s) -
Goodman Murray,
Gilon Chaim,
Kirshenbaum Gerald S.,
Knobler Yehuda
Publication year - 1972
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197200087
Subject(s) - copolymer , chemistry , hydroxylamine , polymer chemistry , cleavage (geology) , polyester , amino acid , catalysis , organic chemistry , polymer , biochemistry , geotechnical engineering , fracture (geology) , engineering
Copolymers of the typewere synthesized and characterized. The syntheses of these copolymers were achieved by copolymerization of an α‐amino acid N‐carboxy anhydride and an α‐hydroxy acid anhydrosulfite in the presence of a catalyst. The copolymers were characterized by spectroscopic methods including infrared, circular dichroism and nuclear magnetic resonance. Specific cleavage of the ester bonds by hydroxylamine in the cold confirmed the A‐B block structure where the A represents the poly(amino acid) segment and the B indicates the polyester segment. Measurements by nmr and viscosity indicate that the blocks consist of short chain lengths.