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Synthesis and Polymerization of p ‐Vinyl‐β‐Phenylethylamine
Author(s) -
Tahan M.,
Lender N.,
Zilkha A.
Publication year - 1972
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197200084
Subject(s) - chemistry , monomer , polymerization , bisulfite , vinyl chloride , ethylamine , polymer chemistry , hydrochloride , vinyl polymer , vinyl ether , polymer , organic chemistry , copolymer , biochemistry , gene expression , dna methylation , gene
p ‐Vinyl benzyl chloride was converted to p ‐vinyl benzyl cyanide which was reduced to p ‐vinyl‐β‐phenyl‐ethylamine with lithium aluminium hydride. The amine gave an insoluble polymer on heating with azo initiator, but soluble polymer was obtained on polymerizing p ‐vinyl‐β‐phenylethylamine hydrochloride in aqueous solution by bisulfite/persulfate initiator. Preliminary pharmacological tests carried out on poly‐ p ‐vinyl‐β‐phenylethylamine hydrochloride and its monomer, showed that the polymer was much more toxic, it showed a tranquilizer/sedative action compared to the monomer which showed excitor symptoms.