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Preparation of (+)‐3‐Quinuclidinol
Author(s) -
Kalir A.,
Sali E.,
Shirin E.
Publication year - 1971
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197100040
Subject(s) - chemistry , hydrogenolysis , tartrate , enantiomer , salt (chemistry) , base (topology) , alcohol , enantiomeric excess , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , enantioselective synthesis , mathematical analysis , mathematics
The separation of 3‐quinuclidinol into its optical isomers and isolation of the not previously attainable (+) — enantiomer was accomplished by N‐benzylation of the amino alcohol, conversion of the quaternary base into the dibenzoyl‐D‐tartrate salt, and hydrogenolysis.