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N‐Alkylation During the Removal of a Carbamate‐Type Protecting Group
Author(s) -
Sheradsky T.,
Salemnick G.,
Frankel M.
Publication year - 1971
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197100039
Subject(s) - chemistry , alkylation , carbamate , group (periodic table) , protecting group , organic chemistry , combinatorial chemistry , catalysis , alkyl
Acidolysis of 2‐(p‐biphenylyl)isopropyl N‐(5‐nitro‐2‐pyridyloxy)carbamate (IV) resulted in loss of carbon dioxide and formation of N‐2‐(p‐biphenylyl)isopropyl‐O‐(5‐nitro‐2‐pyridyl) hydroxylamine (V). The mechanism of this unusual reaction is discussed.