Premium
The Use of Amberlyst Ion‐Exchanger in the Picolyl Ester Method of Peptide Synthesis
Author(s) -
Burton J.,
Young G. T.
Publication year - 1971
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.197100030
Subject(s) - chemistry , yield (engineering) , salt (chemistry) , peptide synthesis , ion exchange , phenylalanine , organic chemistry , peptide , ion exchange resin , ion , amino acid , biochemistry , materials science , metallurgy
The use of Amberlyst‐15 ion‐exchanger (as the 3‐bromopyridinium salt) for the separation of coupling product in the picolyl ester method of peptide synthesis is exemplified by a description of the synthesis of N‐butoxycarbonyl‐O‐benzyl‐L‐seryl‐S‐benzylthiomethyl‐L‐cysteinylglycyl‐L‐phenylalanine 4‐picolyl ester, in 76.5% overall yield, from phenylalanine 4‐picolyl ester dihydrobromide.