Premium
On the Relation Between TSH Administration In Vivo and the Activities of Several Glycolytic, Pentose Phosphate Pathway and Tricarboxylic Acid Cycle Enzymes in the Rat Thyroid Gland
Author(s) -
Kopelovich L.
Publication year - 1969
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196900074
Subject(s) - pentose phosphate pathway , thyroid , chemistry , citric acid cycle , hexokinase , glycolysis , medicine , endocrinology , enzyme , in vivo , biochemistry , intracellular , biology , microbiology and biotechnology
The effect of TSH, administered In vivo, on the activities of enzymes concerned with glycolysis, pentose phosphate pathway and the tricarboxylic acid cycle in the rat thyroid gland was investigated. In control animals, the activity pattern of these enzymes closely resembles that found in sheep thyroid gland. The apparent increase in the specific activity of all enzymes during TSH administration was attributed to a concomitant loss of protein from the follicular lumen of the thyroid gland by intracellular proteolysis. However, TSH seems to affect the Intracellular distribution of hexokinase activity in the rat thyroid gland. It Is suggested that the latter observation could explain, in part, the apparent increase in glucose utilization by TSH in this tissue.