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An Approach to the Enzymatic Cleavage of Serine Peptide Bonds
Author(s) -
Patchornik A.,
Wilchek M.,
Zioudrou C.
Publication year - 1969
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196900073
Subject(s) - chemistry , serine , trypsin , peptide , cleavage (geology) , enzymatic hydrolysis , hydrolysis , peptide bond , residue (chemistry) , enzyme , cysteamine , biochemistry , stereochemistry , geotechnical engineering , fracture (geology) , engineering
The reaction of O‐p‐toluenesulfonyl and O‐methanesulfonyl‐L‐serine peptides with cysteamine yields the corresponding S‐β‐aminoethylcysteine peptides (thialysine peptides). The thialysine peptides can be hydrolysed by trypsin. The method can be used for sequence studies.