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Studies on Rat Liver Glutamine Synthetase
Author(s) -
Gutter B.,
SpiegelsteinKlarfeld Hanna,
Lichtenstein N.
Publication year - 1969
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196900012
Subject(s) - glutamine synthetase , chemistry , glutamine , enzyme , biochemistry , ammonia , amino acid
Rat liver glutamine synthetase is activated by Mg ++ and by Mn ++ . Optimal activity of the Mg ++ activated synthetase occurred at about pH 7.8. The pH optimum of the Mn ++ activated enzyme varied from 6.2 at low Mn ++ concentrations to 4.4 at high Mn ++ concentrations. α‐N‐Ethyl‐L‐glutamine inhibits the synthetase activity. The inhibition is of a mixed type. The synthetase is also inhibited, to a lesser degree, by α‐N‐propyl‐L‐glutamine but not by α‐N‐butyl‐L‐glutamine.