Photosensitized Dimerization of Thymine and Cytosine in DNA | Zendy

BenIshai R. | Zendy; BenHur E. | Zendy; Hornfeld Y. | Zendy

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Photosensitized Dimerization of Thymine and Cytosine in DNA

Author(s) -

BenIshai R.,

BenHur E.,

Hornfeld Y.

Publication year - 1968

Publication title -

israel journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.908

H-Index - 54

eISSN - 1869-5868

pISSN - 0021-2148

DOI - 10.1002/ijch.196800094

Subject(s) - chemistry , thymine , cytosine , pyrimidine dimer , dna , photochemistry , acetophenone , dimer , stereochemistry , acetone , photosensitizer , biochemistry , dna damage , organic chemistry , catalysis

Thymine and cytosine homo‐ and heterodimers ate produced when E. coli DNA is irradiated at wavelength > 300 mμ in the presence of acetone as photosensitizer. Employing acetophenone as sensitizer only thymine containing dimers are obtained. In heat denatured DNA photosensitized dimerization of thymine occurs in a higher proportion of the TT dinucleotide sequences than in native DNA and the trans‐syn thymine dimer isomer is formed as a minor photoproduct.

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