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Approach to the Controlled Synthesis of Nucleopeptides I. N ε ‐(6‐Purinoyl‐L‐Lysine and β‐(5‐Uracilyl)‐Dl‐Alanine
Author(s) -
Vincze A.,
Lachman Ch.,
Cohen S.
Publication year - 1968
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196800081
Subject(s) - chemistry , lysine , alanine , acylation , hydrolysis , condensation , acid hydrolysis , amino acid , stereochemistry , organic chemistry , biochemistry , catalysis , physics , thermodynamics
N ε ‐(6‐purinoyl)‐L‐lysine has been prepared by acylation of L‐lysine copper complex or N α ‐carbobenzoxy‐L‐lysine with 6‐trichloromethylpurine followed by the removal of the protecting group. β‐(5‐uracilyl)‐DL‐alanine has been prepared by condensation of 5‐chloro‐methyluracil with diethyl acetamidomalonate, followed by acid hydrolysis.