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Some N‐Substituted 6‐Methylpurines
Author(s) -
Vincze A.,
Cohen Sasson
Publication year - 1966
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196600004
Subject(s) - chemistry , methylamine , purine , methylation , column chromatography , purine metabolism , amination , nitro , formaldehyde , chromatography , organic chemistry , medicinal chemistry , biochemistry , catalysis , dna , alkyl , enzyme
6,9‐Dimethylpurine was prepared from 6‐methyluracil; the key step in this procedure is the selective amination of 2,4‐dichloro‐5‐nitro‐6‐methyluracil with methylamine. Methylation of 6‐methylpurine, gave a mixture of 6,9‐dimethyl‐and 3,6‐dimethyl‐purine, separable by column chromatography. An improved procedure for the preparation of 6‐methyl‐9‐(β‐D‐ribofuranosyl) purine is presented.