Some N‐Substituted 6‐Methylpurines | Zendy

Vincze A. | Zendy; Cohen Sasson | Zendy

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Some N‐Substituted 6‐Methylpurines

Author(s) -

Vincze A.,

Cohen Sasson

Publication year - 1966

Publication title -

israel journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.908

H-Index - 54

eISSN - 1869-5868

pISSN - 0021-2148

DOI - 10.1002/ijch.196600004

Subject(s) - chemistry , methylamine , purine , methylation , column chromatography , purine metabolism , amination , nitro , formaldehyde , chromatography , organic chemistry , medicinal chemistry , biochemistry , catalysis , dna , alkyl , enzyme

6,9‐Dimethylpurine was prepared from 6‐methyluracil; the key step in this procedure is the selective amination of 2,4‐dichloro‐5‐nitro‐6‐methyluracil with methylamine. Methylation of 6‐methylpurine, gave a mixture of 6,9‐dimethyl‐and 3,6‐dimethyl‐purine, separable by column chromatography. An improved procedure for the preparation of 6‐methyl‐9‐(β‐D‐ribofuranosyl) purine is presented.

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