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The Preparation and Properties of Some Halomethylpyrimidines
Author(s) -
Ashani Y.,
Cohen S.
Publication year - 1965
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196500026
Subject(s) - chemistry , halogen , ring (chemistry) , reactivity (psychology) , computational chemistry , electron transfer , dissociation (chemistry) , abstraction , inductive effect , photochemistry , medicinal chemistry , stereochemistry , organic chemistry , epistemology , medicine , philosophy , alkyl , alternative medicine , pathology
Halogen reactivity in various 5‐halomethylpyrimidines is ascribed to mesomeric electron transfer from the ring to the halomethyl group. In the more stable 6‐halomethylpyrimidines, electron abstraction from the ring is of an inductive nature. These effects are reflected in differences in the dissociation constants of corresponding members of the two series.