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Synthesis of Compounds Related to Steroids. Reactions of β‐Methyltricarballylic Acid Anhydride with Benzene and Naphthalene
Author(s) -
Harnik M.
Publication year - 1965
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196500002
Subject(s) - chemistry , naphthalene , benzene , organic chemistry , acid anhydride , derivative (finance) , benzene derivatives , sequence (biology) , chemical synthesis , biochemistry , financial economics , epoxy , economics , in vitro
β‐Methyltricarballylic acid anhydride (I) undergoes an efficient three‐step reaction sequence whereby it is transformed into known intermediates useful in the synthesis of aromatic steroids. Experiments are described in the benzene series leading to the preparation of the tetralone derivative (VIIa), and in the naphthalene series giving the tetrahydrophenanthrene acids (XV) and (XIII).