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The Ionisation Sequence of Hypoxanthine and 6‐Mercaptopurine
Author(s) -
Bergmann F.,
Kleiner M.,
Neiman Z.,
Rashi M.
Publication year - 1964
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196400056
Subject(s) - chemistry , hypoxanthine , bathochromic shift , hypsochromic shift , mercaptopurine , dissociation (chemistry) , purine metabolism , purine , sequence (biology) , stereochemistry , organic chemistry , biochemistry , medicine , physics , quantum mechanics , fluorescence , enzyme
The sequence of acid dissociation in hypoxanthine is 9 (7) → 1 and in 6‐mercaptopurine 1 → 9 (7). In the former compound, formation of either the mono‐ or the bis‐anion is accompanied by bathochromic shifts, in the latter by hypsochromic displacements. Analogous changes are observed upon conversion of these two purines into the respective O‐ and S‐methyl ethers.