Premium
Kinetic Studies on the Methylation of Thiopurines
Author(s) -
Bergmann F.,
Kleiner M.
Publication year - 1963
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.196300061
Subject(s) - chemistry , methyl iodide , mercaptopurine , methylation , alkylation , sulfur , iodide , dimethylformamide , medicinal chemistry , organic chemistry , biochemistry , dna , catalysis , solvent , medicine
Both 6‐mercaptopurine and 6‐thioxanthine, when treated with methyl iodide in dimethylformamide, undergo a two‐step reaction, i.e. first methylation at the sulphur atom, followed by alkylation at N‐3. Reaction; at the sulphur atom of 3‐methyl‐6‐purinethione proceeds 1350 times faster than in 6‐mercaptopurine.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom