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Associations of vitamin D status with colorectal cancer risk and survival
Author(s) -
Zhou Jian,
Ge Xianxiu,
Fan Xikang,
Wang Jiayu,
Miao Lin,
Hang Dong
Publication year - 2021
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33580
Subject(s) - medicine , quartile , vitamin d and neurology , colorectal cancer , gastroenterology , lower risk , incidence (geometry) , cancer , vitamin d deficiency , oncology , confidence interval , physics , optics
Biological evidence suggests that vitamin D has numerous anticancer functions, but the associations between vitamin D status and colorectal cancer (CRC) risk and survival remain inconclusive. Based on UK Biobank, we prospectively evaluated the associations of season‐standardized 25‐hydroxyvitamin D (25(OH)D) concentrations with CRC risk among 360 061 participants, and with survival among 2509 CRC cases. We observed an inverse linear relationship between 25(OH)D concentrations and CRC risk ( P for linearity = .01; HR per 1‐SD increment, 0.95; 95% CI, 0.91‐0.99). Compared to the lowest quartile of 25(OH)D, the highest quartile was associated with a 13% (HR, 0.87; 95% CI, 0.77‐0.98) lower risk of CRC. For CRC survival, compared to those in the lowest quartile of 25(OH)D, cases in the highest quartile had a 20% (HR, 0.80; 95% CI, 0.65‐0.99) lower risk for overall death. Our findings indicate that higher concentrations of serum 25(OH)D are associated with lower incidence and improved survival of CRC, suggesting a role of vitamin D in the pathogenesis of CRC.