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Contemporary management of breast cancer in Nigeria: Insights from an institutional database
Author(s) -
Olasehinde Olalekan,
Alatise Olusegun,
Omisore Adeleye,
Wuraola Funmilola,
Odujoko Oluwole,
Romanoff Anya,
Akinkuolie Akinbolaji,
Arowolo Olukayode,
Adisa Adewale,
Knapp Gregory,
Famurewa Olusola,
Omisile Idowu,
Onabanjo Emmanuella,
Constable Jeremy,
OmoniyiEsan Ganiyat,
Adesunkanmi AbdulRasheed,
Lawal Oladejo,
Kingham Thomas P.
Publication year - 2021
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33484
Subject(s) - medicine , breast cancer , radiation therapy , cohort , stage (stratigraphy) , disease , cancer , cancer registry , oncology , database , chemotherapy , surgery , paleontology , computer science , biology
High‐quality data are needed to guide interventions aimed at improving breast cancer outcomes in sub‐Saharan Africa. We present data from an institutional breast cancer database to create a framework for cancer policy and development in Nigeria. An institutional database was queried for consecutive patients diagnosed with breast cancer between January 2010 and December 2018. Sociodemographic, diagnostic, histopathologic, treatment and outcome variables were analyzed. Of 607 patients, there were 597 females with a mean age of 49.8 ± 12.2 years. Most patients presented with a palpable mass (97%) and advanced disease (80.2% ≥ Stage III). Immunohistochemistry was performed on 21.6% (131/607) of specimens. Forty percent were estrogen receptor positive, 32.8% were positive for HER‐2 and 43.5% were triple negative. Surgery was performed on 49.9% (303/607) of patients, while 72% received chemotherapy and 7.9% had radiotherapy. At a median follow‐up period of 20.5 months, the overall survival was 43.6% (95% CI −37.7 to 49.5). Among patients with resectable disease, 18.8% (57/303) experienced a recurrence. Survival was significantly better for early‐stage disease (I and II) compared to late‐stage disease (III or IV) (78.6% vs 33.3%, P < .001). Receipt of adjuvant radiotherapy after systemic chemotherapy was associated with improved survival in patients with locally advanced disease (68.5%, CI −46.3 to 86 vs 51%, CI 38.6 to 61.9, P < .001). This large cohort highlights the dual burden of advanced disease and inadequate access to comprehensive breast cancer care in Nigeria. There is a significant potential for improving outcomes by promoting early diagnosis and facilitating access to multimodality treatment.