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The combined action of monocytic myeloid‐derived suppressor cells and mucosal‐associated invariant T cells promotes the progression of cervical cancer
Author(s) -
Lu Zhimin,
Zhu Mengting,
Marley Jordan Lee,
Bi Kaihuan,
Wang Kangxia,
Zhai Muxin,
Hu Hui,
Guo Peipei,
Li Caihua,
Xu Yuping,
Chen Ya,
Zhou Ping,
Wei Zhaolian,
Jiang Huanhuan,
Cao Yunxia
Publication year - 2020
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33411
Subject(s) - chemokine , immune system , myeloid derived suppressor cell , tumor microenvironment , cd8 , cd38 , immunology , cancer research , cancer cell , cancer , myeloid , medicine , biology , suppressor , stem cell , microbiology and biotechnology , cd34
One of the most common promoters of the initiation and growth of the tumor is an immune disturbance. Numerous immune cells and inflammatory factors play a role in the tumor‐immune microenvironment. However, few studies have investigated the correlation between these immunological events and clinical consequences in cervical cancer. We measured the levels of numerous inflammatory mediators and frequencies of regulatory T cells (Tregs), myeloid‐derived suppressor cells (MDSCs) and mucosal‐associated invariant T (MAIT) cells in peripheral blood (PB) of cervical cancer patients. Cervical cancer patients showed elevated production of interleukin (IL)‐18 and plasma C‐C chemokine ligand (CCL) 3/5. Meanwhile, an accumulation of C‐C chemokine receptor 5 (CCR5) monocytic (Mo)‐MDSCs and Tregs was observed. The cervical cancer group displayed increased frequencies of CD8 + , CD4 + and highly activated CD38 + CD8 + MAIT cells, and reduction of double‐negative (DN) and PD1(CD279 + ) DN MAIT cells. Importantly, it was demonstrated that MAIT cells were positively related to Mo‐MDSCs. Furthermore, an elevated concentration of PD1(CD279 + ) DN MAIT cells was significantly related to increased progression‐free survival of patients with cervical cancer. In conclusion, our study suggests that the combined action of Mo‐MDSCs and MAIT cells might be associated with the progression of cervical cancer, and the frequency of DN MAIT cells in the peripheral blood mononuclear cells was associated with the survival benefit of patients.

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