Effective methylation triage of  HPV  positive women with abnormal cytology in a middle‐income country | Zendy

Ramírez Arianis Tatiana | Zendy; Sánchez Gloria Inés | Zendy; Nedjai Belinda | Zendy; Agudelo María Cecilia | Zendy; Brentnall Adam R. | Zendy; Cuschieri Kate | Zendy; Castañeda Kelly Melisa | Zendy; Cuzick Jack | Zendy; Lorincz Attila T. | Zendy

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Effective methylation triage of HPV positive women with abnormal cytology in a middle‐income country

Author(s) -

Ramírez Arianis Tatiana,

Sánchez Gloria Inés,

Nedjai Belinda,

Agudelo María Cecilia,

Brentnall Adam R.,

Cuschieri Kate,

Castañeda Kelly Melisa,

Cuzick Jack,

Lorincz Attila T.

Publication year - 2020

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.33314

Subject(s) - triage , cytology , methylation , medicine , biology , pathology , medical emergency , genetics , gene

The S5‐methylation test, an alternative to cytology and HPV16/18 genotyping to triage high‐risk HPV‐positive (hrHPV+) women, has not been widely validated in low‐middle‐income countries (LMICs). We compared S5 to HPV16/18 and cytology to detect cervical intraepithelial neoplasia Grade 2 or worse (CIN2+) and CIN3+ in hrHPV+ women selected from a randomized pragmatic trial of 2661 Colombian women with an earlier‐borderline abnormal cytology. We included all hrHPV+ CIN2 and CIN3+ cases (n = 183) age matched to 183

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