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Effective methylation triage of HPV positive women with abnormal cytology in a middle‐income country
Author(s) -
Ramírez Arianis Tatiana,
Sánchez Gloria Inés,
Nedjai Belinda,
Agudelo María Cecilia,
Brentnall Adam R.,
Cuschieri Kate,
Castañeda Kelly Melisa,
Cuzick Jack,
Lorincz Attila T.
Publication year - 2020
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33314
Subject(s) - medicine , cytology , cervical intraepithelial neoplasia , confidence interval , colposcopy , gynecology , cervical cancer , gastroenterology , obstetrics , cancer , pathology
The S5‐methylation test, an alternative to cytology and HPV16/18 genotyping to triage high‐risk HPV‐positive (hrHPV+) women, has not been widely validated in low‐middle‐income countries (LMICs). We compared S5 to HPV16/18 and cytology to detect cervical intraepithelial neoplasia Grade 2 or worse (CIN2+) and CIN3+ in hrHPV+ women selected from a randomized pragmatic trial of 2661 Colombian women with an earlier‐borderline abnormal cytology. We included all hrHPV+ CIN2 and CIN3+ cases (n = 183) age matched to 183