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Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome
Author(s) -
LadiganBadura Swetlana,
Vangala Deepak B.,
Engel Christoph,
Bucksch Karolin,
Hueneburg Robert,
Perne Claudia,
Nattermann Jacob,
SteinkeLange Verena,
Rahner Nils,
Schackert Hans K.,
Weitz Jürgen,
Kloor Matthias,
Kuhlkamp Judith,
Nguyen Huu Phuc,
Moeslein Gabriela,
Strassburg Christian,
Morak Monika,
HolinskiFeder Elke,
Buettner Reinhard,
Aretz Stefan,
Loeffler Markus,
Schmiegel Wolff,
Pox Christian,
Schulmann Karsten
Publication year - 2020
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33294
Subject(s) - medicine , endoscopy , gastroenterology , lynch syndrome , prospective cohort study , cancer , cohort , colorectal cancer , dna mismatch repair
In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of the German Consortium for Familial Intestinal Cancer . In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3 years. Forty‐nine GC events were observed in 47 patients. MLH1 (n = 21) and MSH2 (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early‐stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; P = .0231). Thirty‐two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28‐66). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30.