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The role of SIRT2 in cancer: A novel therapeutic target
Author(s) -
Chen Guangyuan,
Huang Peng,
Hu Cong
Publication year - 2020
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33118
Subject(s) - sirt2 , sirtuin , cancer , carcinogenesis , cancer research , mechanism (biology) , biology , function (biology) , computational biology , medicine , microbiology and biotechnology , genetics , gene , acetylation , philosophy , epistemology
Sirtuin 2 (SIRT2) belongs to the sirtuins family. It exists in many tissues and organs of the human body and regulates a wide range of biological functions. Studies have found that the abnormal expression of SIRT2 was associated with a variety of malignant tumors. SIRT2 possesses an important role in tumorigenesis, with both tumor‐promoting and tumor‐suppressing function. However, the mechanisms in which SIRT2 plays the roles in cancer are still controversial. This article reviews the role and molecular mechanism of SIRT2 in tumor evolution, and provides ideas for future research in this field, to guide the targeted therapy and drug development of related malignancies.