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Association between inflammatory bowel disease and prostate cancer: A large‐scale, prospective, population‐based study
Author(s) -
Meyers Travis J.,
Weiner Adam B.,
Graff Rebecca E.,
Desai Anuj S.,
Cooley Lauren Folgosa,
Catalona William J.,
Hanauer Stephen B.,
Wu Jennifer D.,
Schaeffer Edward M.,
Abdulkadir Sarki A.,
Kundu Shilajit D.,
Witte John S.
Publication year - 2020
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33048
Subject(s) - medicine , hazard ratio , prospective cohort study , ulcerative colitis , inflammatory bowel disease , prostate cancer , population , proportional hazards model , cohort , cancer , body mass index , risk factor , confidence interval , oncology , disease , environmental health
Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD is also a risk factor for prostate cancer (PC) require further investigation. We studied 218 084 men in the population‐based UK Biobank cohort, aged 40 to 69 at study entry between 2006 and 2010, with follow‐up through mid‐2015. We assessed the association between IBD and subsequent PC using multivariable Cox regression analyses, adjusting for age at assessment, ethnic group, UK region, smoking status, alcohol drinking frequency, body mass index, Townsend Deprivation Index, family history of PC and previous prostate‐specific antigen testing. Mean age at study entry was 56 years, 94% of the men were white, and 1.1% (n = 2311) had a diagnosis of IBD. After a median follow‐up of 78 months, men with IBD had an increased risk of PC (adjusted hazard ratio [aHR] = 1.31, 95% confidence interval [CI] = 1.03‐1.67, P = .029). The association with PC was only among men with the ulcerative colitis (UC; aHR = 1.47, 95% CI = 1.11‐1.95, P = .0070), and not Crohn's disease (aHR 1.06, 95% CI = 0.63‐1.80, P = .82). Results are limited by lack of data on frequency of health care interactions. In a large‐scale, prospective cohort study, we detected an association between IBD, and UC specifically, with incident PC diagnosis.