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Genetic polymorphisms in the cag pathogenicity island of Helicobacter pylori and risk of stomach cancer and high‐grade premalignant gastric lesions
Author(s) -
Canzian Federico,
Rizzato Cosmeri,
Obazee Ofure,
Stein Angelika,
FloresLuna Lourdes,
CamorlingaPonce Margarita,
MendezTenorio Alfonso,
Vivas Jorge,
Trujillo Esperanza,
Jang Hyejong,
Chen Wei,
Kasamatsu Elena,
Bravo Maria Mercedes,
Torres Javier,
Muñoz Nubia,
Kato Ikuko
Publication year - 2020
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.33032
Subject(s) - caga , helicobacter pylori , biology , intestinal metaplasia , population , cancer , stomach cancer , gastritis , gastroenterology , stomach , dysplasia , atrophic gastritis , medicine , genetics , gene , virulence , environmental health
Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongly associated with the risk of gastric cancer (GC) and its premalignant precursors. The cag pathogenicity island (cagPAI) is a region of the Hp genome encoding for key molecular machinery involved in the infection process. Following a sequencing study, we selected 50 genetic polymorphisms located in seven cagPAI genes and tested their associations with the risk of advanced gastric premalignant lesions and GC in 1220 subjects from various Latin American populations showing the whole spectrum of phenotypes from gastritis to GC. We found that three polymorphisms of cagA are associated with the risk of advanced gastric premalignant lesions (incomplete intestinal metaplasia [ie, Type 2 and 3] or dysplasia), and that six polymorphisms located in cagA , cagL and cagI were associated with risk of GC. When corrected for multiple testing none of the associations were statistically significant. However, scores built by integrating the individual polymorphisms were significantly associated with the risk of advanced gastric premalignant lesions and GC. These results have the potential of establishing markers for risk stratification in the general population, in view of targeting Hp eradication to high‐risk population groups.