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Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11
Author(s) -
Ungaro Federica,
Colombo Piergiuseppe,
Massimino Luca,
Ugolini Giovanni Stefano,
Correale Carmen,
Rasponi Marco,
Garlatti Valentina,
Rubbino Federica,
Tacconi Carlotta,
Spaggiari Paola,
Spinelli Antonino,
Carvello Michele,
Sacchi Matteo,
Spanò Salvatore,
Vetrano Stefania,
Malesci Alberto,
PeyrinBiroulet Laurent,
Danese Silvio,
D'Alessio Silvia
Publication year - 2019
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.32286
Subject(s) - stromal cell , lymphatic endothelium , lymphatic system , colorectal cancer , biology , extracellular matrix , cancer research , tumor microenvironment , metastasis , tumor progression , pathology , immunology , cancer , medicine , microbiology and biotechnology , genetics , tumor cells
Colorectal cancer (CRC) is one of the most malignant tumors worldwide. Stromal cells residing in the tumor microenvironment strongly contribute to cancer progression through their crosstalk with cancer cells and extracellular matrix. Here we provide the first evidence that CRC‐associated lymphatic endothelium displays a distinct matrisome‐associated transcriptomic signature, which distinguishes them from healthy intestinal lymphatics. We also demonstrate that CRC‐associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression. Our data provide new insights into lymphatic contribution to CRC growth, aside from their conventional role as conduits of metastasis.