Premium
Interaction between genetic ancestry and common breast cancer susceptibility variants in Colombian women
Author(s) -
Torres Diana,
Lorenzo Bermejo Justo,
Garcia Mesa Karen,
Gilbert Michael,
Briceño Ignacio,
PohlZeidler Svenja,
González Silos Rosa,
Boekstegers Felix,
Plass Christoph,
Hamann Ute
Publication year - 2019
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.32023
Subject(s) - genetic genealogy , demography , logistic regression , breast cancer , allele , genetic variants , medicine , ancestry informative marker , cancer , oncology , genetics , genotype , biology , allele frequency , population , gene , sociology
Latino women show lower incidences of breast cancer (BC) than non‐Hispanic whites. Large‐scale genetic association studies have identified variants robustly associated with BC risk in European women. We examine here the relevance of these variants to Colombian BC and possible interactions with genetic ancestry. Native American, European and African proportions were estimated for 1022 Colombian BC cases and 1023 controls. Logistic regression was applied to assess the association between 78 variants and BC risk and interactions between the variants and ancestry proportions. We constructed a multifactorial risk score combining established BC risk factors, associated risk variants and individual ancestry proportions. Each 1% increase in the Native American proportion translated into a 2.2% lower BC risk (95% CI: 1.4–2.9). Thirteen variants were associated with BC in Colombian women, with allele frequencies and risk effects partially different from European women. Ancestry proportions moderated the risk effects of two variants. The ability of Native American proportions to separate Colombian cases and controls (area‐under‐the‐curve (AUC) = 0.61) was similar to the discriminative ability of family history of BC in first‐degree female relatives (AUC = 0.58) or the combined effect of all 13 associated risk variants (AUC = 0.57). Our findings demonstrate ample potential for individualized BC prevention in Hispanic women taking advantage of individual Native American proportions, information on established susceptibility factors and recently identified common risk variants.