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Pre‐diagnostic circulating insulin‐like growth factor‐I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition
Author(s) -
Lin Crystal,
Travis Ruth C.,
Appleby Paul N.,
Tipper Sarah,
Weiderpass Elisabete,
ChangClaude Jenny,
Gram Inger T.,
Kaaks Rudolf,
Kiemeney Lambertus A.,
Ljungberg Börje,
Tumino Rosario,
Tjønneland Anne,
Roswall Nina,
Overvad Kim,
BoutronRuault MarieChristine,
Manciniveri Francesca Romana,
Severi Gianluca,
Trichopoulou Antonia,
Masala Giovanna,
Sacerdote Carlotta,
Agnoli Claudia,
Panico Salvatore,
BuenodeMesquita Bas,
Peeters Petra H.,
SalamancaFernández Elena,
Chirlaque MariaDolores,
Ardanaz Eva,
Dorronsoro Miren,
Menéndez Virginia,
LujánBarroso Leila,
Liedberg Fredrik,
Freisling Heinz,
Gunter Marc,
Aune Dagfinn,
Cross Amanda J.,
Riboli Elio,
Key Timothy J.,
PerezCornago Aurora
Publication year - 2018
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.31650
Subject(s) - european prospective investigation into cancer and nutrition , medicine , bladder cancer , prospective cohort study , cancer , odds ratio , risk factor , oncology , nested case control study , cohort
Previous in vitro and case–control studies have found an association between the insulin‐like growth factor (IGF)‐axis and bladder cancer risk. Circulating concentrations of IGF‐I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre‐diagnostic circulating IGF‐I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre‐diagnostic plasma concentrations of IGF‐I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow‐up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre‐diagnostic circulating IGF‐I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66–1.24, p trend = 0.40) or UCC ( n of cases = 776; 0.91, 0.65–1.26, p trend = 0.40). There was no significant evidence of heterogeneity in the association of IGF‐I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis ( p heterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF‐I concentrations and bladder cancer risk.