Premium
Toremifene, rather than tamoxifen, might be a better option for the adjuvant endocrine therapy in CYP2D6*10T/T genotype breast cancer patients in China
Author(s) -
Lan Bo,
Ma Fei,
Chen Shanshan,
Wang Wenna,
Li Qiao,
Fan Ying,
Luo Yang,
Cai Ruigang,
Wang Jiayu,
Yuan Peng,
Zhang Pin,
Li Qing,
Xu Binghe
Publication year - 2018
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.31639
Subject(s) - toremifene , tamoxifen , medicine , breast cancer , adjuvant , genotype , oncology , hazard ratio , adjuvant therapy , cancer , gynecology , gastroenterology , biology , confidence interval , genetics , gene
Toremifene (TOR) is a valid and safe alternative to tamoxifen (TAM) for adjuvant endocrine therapy in breast cancer patients with a metabolic pathway that differs from that of TAM. TOR might have a therapeutic advantage in certain subgroups of patients, such as Chinese women with the CYP2D6 *10 (c.100C > T) T/T genotype, who would get less benefit when receiving adjuvant TAM treatment. A total of 230 breast cancer patients who received adjuvant TAM ( n = 115) or TOR ( n = 115) at the National Cancer Center were analyzed. The CYP2D6 *10 genotype was not significantly associated with DFS in patients who received TOR ( p = 0.737). Patients treated with TOR had a higher 5‐year disease‐free survival (DFS) rate than those treated with TAM (89.6% vs. 80.9%, p = 0.009). TOR treatment remained an independent prognostic marker of DFS in multivariate analysis compared with TAM (hazard ratio = 0.51; p = 0.014). For all of the 50 CYP2D6 *10 T/T genotype patients, TOR treatment group had a significantly higher 5‐year DFS rate than TAM group (90.9% vs. 67.9%, p = 0.031). For the remaining 170 CYP2D6 *10 C/C or C/T genotype patients, there was no significant difference between the 5‐year DFS rates of the TOR and TAM groups (89.2% vs. 85.1%, p = 0.188). The advantage of adjuvant TOR over TAM in Chinese breast cancer patients might be caused by the significant benefit obtained by the CYP2D6 *10 T/T patients, who accounted for one‐fifth of the overall population. TOR might be a good option for adjuvant endocrine therapy in this subgroup of patients in China.