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Physical activity and the risk of colorectal cancer in Lynch syndrome
Author(s) -
Dashti S. Ghazaleh,
Win Aung Ko,
Hardikar Sheetal S.,
Glombicki Stephen E.,
Mallenahalli Sheila,
Thirumurthi Selvi,
Peterson Susan K.,
You Y. Nancy,
Buchanan Daniel D.,
Figueiredo Jane C.,
Campbell Peter T.,
Gallinger Steven,
Newcomb Polly A.,
Potter John D.,
Lindor Noralane M.,
Le Marchand Loic,
Haile Robert W.,
Hopper John L.,
Jenkins Mark A.,
BasenEngquist Karen M.,
Lynch Patrick M.,
Pande Mala
Publication year - 2018
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.31611
Subject(s) - colorectal cancer , lynch syndrome , medicine , hazard ratio , oncology , population , proportional hazards model , cancer , cohort , cohort study , cancer registry , family history , confidence interval , dna mismatch repair , environmental health
Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little is known about its relationship with colorectal cancer risk in people with Lynch syndrome, carriers of inherited pathogenic mutations in genes affecting DNA mismatch repair (MMR). We studied a cohort of 2,042 MMR gene mutations carriers ( n = 807, diagnosed with colorectal cancer), from the Colon Cancer Family Registry. Self‐reported physical activity in three age‐periods (20–29, 30–49 and ≥50 years) was summarized as average metabolic equivalent of task hours per week (MET‐hr/week) during the age‐period of cancer diagnosis or censoring (near‐term exposure) and across all age‐periods preceding cancer diagnosis or censoring (long‐term exposure). Weighted Cox regression was used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for the association between physical activity and colorectal cancer risk. Near‐term physical activity was associated with a small reduction in the risk of colorectal cancer (HR ≥35 vs . <3.5 MET‐hr/week, 0.71; 95% CI, 0.53–0.96). The strength and direction of associations were similar for long‐term physical activity, although the associations were not nominally significant. Our results suggest that physical activity is inversely associated with the risk of colorectal cancer for people with Lynch syndrome; however, further confirmation is warranted. The potential modifying effect of physical activity on colorectal cancer risk in people with Lynch syndrome could be useful for risk prediction and support counseling advice for lifestyle modification to reduce cancer risk.