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Serologic markers of viral infection and risk of non‐ H odgkin lymphoma: A pooled study of three prospective cohorts in C hina and S ingapore
Author(s) -
Bassig Bryan A.,
WillhauckFleckenstein Martina,
Shu XiaoOu,
Koh WoonPuay,
Gao YuTang,
Purdue Mark P.,
Xiang YongBing,
AdamsHaduch Jennifer,
Wang Renwei,
Brenner Nicole,
Waterboer Tim,
Michel Angelika,
Ji BuTian,
Hosgood H. Dean,
Rabkin Charles S.,
Yang Gong,
Wong Jason Y.Y.,
Zhang Jinming,
Hu Wei,
Seow Wei Jie,
Chow WongHo,
Pawlita Michael,
Zheng Wei,
Yuan JianMin,
Lan Qing,
Rothman Nathaniel
Publication year - 2018
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.31385
Subject(s) - serology , medicine , odds ratio , immunology , hepatitis b virus , lymphoma , population , antibody , virology , antigen , virus , environmental health
Incidence rates of non‐Hodgkin lymphoma (NHL) and distributions of certain viruses differ between East Asian and Western populations. There are limited data on associations between serologic markers of multiple viral infections in pre‐diagnostic blood and NHL risk in East Asians. We conducted a nested case‐control study of 214 NHL cases and 214 matched controls from three population‐based prospective cohorts in Shanghai and Singapore. Antibodies against antigens from herpesviruses, Hepatitis B (HBV) and C (HCV) virus and polyomaviruses were measured in plasma or serum using fluorescent bead‐based multiplex assays. Conditional logistic regression was used to evaluate associations between antibody levels and NHL risk. An increased risk of NHL was observed for higher compared to lower EA‐D (Odds Ratio (OR) = 2.04, 95% Confidence Interval (CI) = 1.10‐3.81; p trend = 0.005) and ZEBRA (OR = 2.17, 95% CI = 0.96‐4.89; p trend = 0.008) Epstein‐Barr Virus (EBV) antibodies, as well as for antibody seropositivity against the IE1A human herpesvirus‐6 (HHV‐6) antigen (OR = 1.85, 95% CI = 1.04‐3.29). An increased NHL risk was also observed for higher compared to lower antibodies against the HBV‐HBc and HBe antigens. An increased risk of NHL in relation to EBV and HBV infection in East Asians is consistent with findings in several studies of Western populations, suggesting similar viral risk factors for NHL in these diverse populations with distinct patterns of NHL. The association between HHV‐6 antibodies and NHL has not previously been reported in a prospective study in this population and will require replication.