Premium
Deciphering the roles of FOXO1 in human neoplasms
Author(s) -
Jiang Shuai,
Li Tian,
Yang Zhi,
Hu Wei,
Yang Yang
Publication year - 2018
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.31338
Subject(s) - foxo1 , forkhead transcription factors , biology , cancer research , bioinformatics , computational biology , transcription factor , genetics , gene
Neoplasms constituted an enormous burden and contributed to an estimated 8.2 million deaths in 2012 worldwide. FOXO1 (forkhead box O1), a member of the forkhead box (FOX) family, is a transcriptional factor involved in diverse cellular functions. Herein, we concentrate on recent studies of the antineoplastic roles of FOXO1 in neoplasms. This article may serve as a guide for future research and identify FOXO1 as a potent therapeutic target in neoplasms.