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Anti‐Müllerian hormone and risk of ovarian cancer in nine cohorts
Author(s) -
Jung Seungyoun,
Allen Naomi,
Arslan Alan A.,
Baglietto Laura,
Barricarte Aurelio,
Brinton Louise A.,
Egleston Brian L.,
Falk Roni T.,
Fortner Renée T.,
Helzlsouer Kathy J.,
Gao Yutang,
Idahl Annika,
Kaaks Rudolph,
Krogh Vittorio,
Merritt Melissa A.,
Lundin Eva,
OnlandMoret N. Charlotte,
Rinaldi Sabina,
Schock Helena,
Shu XiaoOu,
Sluss Patrick M.,
Staats Paul N.,
Sacerdote Carlotta,
Travis Ruth C.,
Tjønneland Anne,
Trichopoulou Antonia,
Tworoger Shelley S.,
Visvanathan Kala,
Weiderpass Elisabete,
ZeleniuchJacquotte Anne,
Dorgan Joanne F.
Publication year - 2017
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.31058
Subject(s) - anti müllerian hormone , medicine , ovarian cancer , odds ratio , quartile , ovarian reserve , oncology , case control study , logistic regression , cancer , gynecology , confidence interval , hormone , endocrinology , physiology , biology , pregnancy , infertility , genetics
Animal and experimental data suggest that anti‐Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case‐control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme‐linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable‐adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable‐adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59–1.67) (P trend : 0.91). The association did not differ by age at blood draw or oral contraceptive use (all P heterogeneity : ≥0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all P heterogeneity : ≥0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer.