Premium
Different miR‐21‐3p isoforms and their different features in colorectal cancer
Author(s) -
Jiao Weijuan,
Leng Xueqin,
Zhou Qun,
Wu Yayun,
Sun Lina,
Tan Yan,
Ni Hengli,
Dong Xiaoqiang,
Shen Tong,
Liu Yao,
Li Jianming
Publication year - 2017
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.30902
Subject(s) - microsatellite instability , colorectal cancer , microrna , gene isoform , oncogene , cancer research , biology , cancer , in vivo , phenotype , gene , oncology , medicine , bioinformatics , genetics , microsatellite , cell cycle , allele
MiR‐21, the only microRNA (miRNA) found to be overexpressed in any type of solid tumor, its guide stand, miR‐21‐5p, has been studied a lot in colorectal cancer (CRC); however, few researchers focused on its passenger strand, miR‐21‐3p. In our study, based on The Cancer Genome Atlas (TCGA) data, we found that there were more varieties and quantities of miR‐21‐3p isoforms in microsatellite instability (MSI)‐type CRC. We further examined the role of miR‐21‐3p by in vitro and in vivo studies. MiR‐21‐3p may be an oncogene in CRC by promoting cellular mobility through epithelial–mesenchymal transition. However, different isoforms, especially miR‐21‐3p 0 | 2, may be a favorable prognostic marker for CRC survival, probably due to increased complementary effect of miR‐21‐5p and/or target genes. Further study investigating the underlying mechanism of miRNA isoforms is needed.