Premium
Thyroid neoplasia risk is increased nearly 30 years after the Chernobyl accident
Author(s) -
Tronko Mykola,
Brenner Alina V.,
Bogdanova Tetiana,
Shpak Victor,
Oliynyk Valeriy,
Cahoon Elizabeth K.,
Drozdovitch Vladimir,
Little Mark P.,
Tereshchenko Valeriy,
Zamotayeva Galyna,
Terekhova Galyna,
Zurnadzhi Lyudmila,
Hatch Maureen,
Mabuchi Kiyohiko
Publication year - 2017
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.30857
Subject(s) - chernobyl nuclear accident , medicine , thyroid , accident (philosophy) , environmental health , philosophy , epistemology
To evaluate risk of thyroid neoplasia nearly 30 years following exposure to radioactive iodine (I‐131) from the 1986 Chernobyl nuclear accident, we conducted a fifth cycle of thyroid screening of the Ukrainian‐American cohort during 2012–2015, following four previous screening cycles started in 1998. We identified 47 thyroid cancers (TC) and 33 follicular adenomas (FA) among 10,073 individuals who were <18 years at the time of the accident and had a mean I‐131 dose of 0.62 Gy. We found a significant I‐131 dose response for both TC and FA, with an excess odd ratio per Gy of 1.36 (95% CI: 0.39–4.15) and 2.03 (95% CI: 0.55–6.69), respectively. The excess risk of malignant and benign thyroid neoplasia persists nearly three decades after exposure and underscores the importance of continued follow‐up of this cohort to characterize long‐term pattern of I‐131 risk.