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The role of metabolic reprogramming in γ‐herpesvirus‐associated oncogenesis
Author(s) -
Lo Angela KwokFung,
Dawson Christopher W.,
Young Lawrence S.,
Lo KwokWai
Publication year - 2017
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.30795
Subject(s) - biology , phenotype , carcinogenesis , metabolic pathway , reprogramming , signal transduction , herpesviridae , cell metabolism , microbiology and biotechnology , virus , immunology , cell , cancer , genetics , gene , viral disease
The γ‐herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ‐herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ‐herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ‐herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ‐herpesviruses alter metabolic phenotypes as a means to support viral infection and long‐term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ‐herpesviruses provide new opportunities for therapeutic intervention.