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Serum 25(OH)D concentration, common variants of the VDR gene and lung cancer occurrence
Author(s) -
Gromowski Tomasz,
Gapska Paulina,
Scott Rodney J.,
Kąklewski Krzysztof,
Marciniak Wojciech,
Durda Katarzyna,
Lener Marcin,
Górski Bohdan,
Cybulski Cezary,
Sukiennicki Grzegorz,
Kaczmarek Katarzyna,
JaworskaBieniek Katarzyna,
PaszkowskaSzczur Katarzyna,
Waloszczyk Piotr,
Lubiński Jan,
Dębniak Tadeusz
Publication year - 2017
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.30740
Subject(s) - medicine , foki , taqi , calcitriol receptor , lung cancer , odds ratio , haplotype , gastroenterology , confidence interval , exact test , population , oncology , genotype , polymorphism (computer science) , gene , genetics , vitamin d and neurology , biology , environmental health
The first aim of our study was to examine the association between common variants in VDR [rs2228570 ( FokI ), rs1544410 ( BsmI ), rs7975232 ( ApaI ), rs731236 ( TaqI ) and rs11568820 ( Cdx2 )] and lung cancer risk in the Polish population. Genotyping and statistical analysis which included Chi‐square test with Yates correction and haplotype frequency analysis were performed on a series of 840 consecutively collected lung cancer patients and 920 healthy controls. The second aim was to evaluate the link between serum 25(OH)D concentration and the number of lung cancers in a subgroup of 200 patients. A separate control group that consisted of 400 matched (by age, sex, smoking habits and the season of blood collection) healthy individuals was used to avoid posterior adjustment on the matched variables. Statistical analysis with the use of Chi‐square test with Yates was performed. We found no statistically significant difference in the distribution of the allels of studied VDR variants among cases and controls. A statistically significant over‐representation of VDR haplotypes: rs731236_A + rs1544410_T [odds ratio (OR) = 2.43, 95% confidence interval (CI) = 1.11–5.32, p < 0.001], rs731236_G + rs1544410_T (OR = 1.54, 95% CI = 1.31–1.81, p < 0.001) and rs731236_G + rs1544410_C (OR = 0.04, 95% CI = 0.03–0.07, p < 0.001) was detected. We found a tendency toward an increased number of lung cancers among individuals with low serum levels of 25(OH)D. To answer the question, whether VDR can be regarded as lung cancer susceptibility gene and low 25(OH)D serum levels is associated with lung cancer occurrences, additional, multicenter study needs to be performed.