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Prediagnostic circulating concentrations of plasma insulin‐like growth factor‐ I and risk of lymphoma in the E uropean P rospective I nvestigation into C ancer and N utrition
Author(s) -
PerezCornago Aurora,
Appleby Paul N.,
Tipper Sarah,
Key Timothy J.,
Allen Naomi E.,
Nieters Alexandra,
Vermeulen Roel,
Roulland Sandrine,
Casabonne Delphine,
Kaaks Rudolf,
Fortner Renee T.,
Boeing Heiner,
Trichopoulou Antonia,
La Vecchia Carlo,
Klinaki Eleni,
Hansen Louise,
Tjønneland Anne,
Bonnet Fabrice,
Fagherazzi Guy,
BoutronRuault MarieChristine,
Pala Valeria,
Masala Giovanna,
Sacerdote Carlotta,
Peeters Petra H.,
BuenodeMesquita H. Bas,
Weiderpass Elisabete,
Dorronsoro Miren,
Quirós J. Ramón,
Barricarte Aurelio,
Gavrila Diana,
Agudo Antonio,
Borgquist Signe,
Rosendahl Ann H.,
Melin Beatrice,
Wareham Nick,
Khaw KayTee,
Gunter Marc,
Riboli Elio,
Vineis Paolo,
Travis Ruth C.
Publication year - 2016
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.30528
Subject(s) - lymphoma , prospective cohort study , odds ratio , medicine , risk factor , oncology , population , cancer , gastroenterology , immunology , endocrinology , environmental health
Insulin‐like growth factor (IGF)‐I has cancer promoting activities. However, the hypothesis that circulating IGF‐I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF‐I concentration was measured in pre‐diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF‐I concentration was not associated with overall lymphoma risk (multivariable‐adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57–1.03], p trend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF‐I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index ( p heterogeneity for all ≥ 0.05). There were no associations between IGF‐I concentration and risk for specific BCL subtypes, T‐cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF‐I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF‐I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF‐I concentrations with lymphoma subtypes.