Premium
Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study
Author(s) -
Jayasekara Harindra,
Reece Jeanette C.,
Buchanan Daniel D.,
Rosty Christophe,
Dashti S. Ghazaleh,
Ait Ouakrim Driss,
Winship Ingrid M.,
Macrae Finlay A.,
Boussioutas Alex,
Giles Graham G.,
Ahnen Dennis J.,
Lowery Jan,
Casey Graham,
Haile Robert W.,
Gallinger Steven,
Le Marchand Loic,
Newcomb Polly A.,
Lindor Noralane M.,
Hopper John L.,
Parry Susan,
Jenkins Mark A.,
Win Aung Ko
Publication year - 2016
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.30153
Subject(s) - medicine , colorectal cancer , hazard ratio , cancer , incidence (geometry) , proportional hazards model , rectum , prospective cohort study , cancer registry , oncology , cohort , confidence interval , gastroenterology , physics , optics
Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous CRC. We examined the associations between personal, tumour‐related and lifestyle risk factors, and risk of metachronous CRC. A total of 7,863 participants with incident colon or rectal cancer who were recruited in the USA, Canada and Australia to the Colon Cancer Family Registry during 1997‐2012, except those identified as high‐risk, for example, Lynch syndrome, were followed up approximately every 5 years. We estimated the risk of metachronous CRC, defined as the first new primary CRC following an interval of at least one year after the initial CRC diagnosis. Observation time started at the age at diagnosis of the initial CRC and ended at the age at diagnosis of the metachronous CRC, last contact or death whichever occurred earliest, or were censored at the age at diagnosis of any metachronous colorectal adenoma. Cox regression was used to derive hazard ratios (HRs) and 95% confidence intervals (CIs). During a mean follow‐up of 6.6 years, 142 (1.81%) metachronous CRCs were diagnosed (mean age at diagnosis 59.8; incidence 2.7/1,000 person‐years). An increased risk of metachronous CRC was associated with the presence of a synchronous CRC (HR = 2.73; 95% CI: 1.30–5.72) and the location of cancer in the proximal colon at initial diagnosis (compared with distal colon or rectum, HR = 4.16; 95% CI: 2.80–6.18). The presence of a synchronous CRC and the location of the initial CRC might be useful for deciding the intensity of surveillance colonoscopy for individuals diagnosed with CRC.