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Association of S treptococcus gallolyticus subspecies gallolyticus with colorectal cancer: Serological evidence
Author(s) -
Butt Julia,
RomeroHernández Beatriz,
PérezGómez Beatriz,
WillhauckFleckenstein Martina,
Holzinger Dana,
Martin Vicente,
Moreno Victor,
Linares Cristina,
DierssenSotos Trinidad,
Barricarte Aurelio,
Tardón Adonina,
Altzibar Jone M.,
MorenoOsset Eduardo,
Franco Francisco,
Requena Rocío Olmedo,
Huerta José María,
Michel Angelika,
Waterboer Tim,
CastañoVinyals Gemma,
Kogevinas Manolis,
Pollán Marina,
Boleij Annemarie,
de Sanjosé Silvia,
del Campo Rosa,
Tjalsma Harold,
Aragonés Nuria,
Pawlita Michael
Publication year - 2015
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29914
Subject(s) - serology , colorectal cancer , medicine , biology , cancer , immunology , genetics , antibody
The colonic opportunist Streptococcus gallolyticus subspecies gallolyticus (SGG) is potentially associated with colorectal cancer (CRC). Large‐scale seroepidemiological data for SGG antibodies and their possible association with CRC is currently missing. Associations between CRC and antibody responses to SGG were examined in 576 CRC cases and 576 controls matched by sex, age and province from a population‐based multicase–control project (MCC‐Spain). MCC‐Spain was conducted between 2008 and 2013 in 12 Spanish provinces. Antibody responses to recombinant affinity‐purified SGG pilus proteins Gallo1569, 2039, 2178 and 2179 were analysed by multiplex serology. Polyomavirus (PyV) JC VP1 and PyV 6 VP1 proteins served as disease‐specificity controls. In the control population, antibody responses to pilus proteins were mostly weak. Antibody responses to individual pilus proteins Gallo2039 (OR: 1.58, 95% CI: 1.09–2.28), Gallo2178 (OR: 1.58, 95% CI: 1.09–2.30) and Gallo2179 (OR: 1.45, 95% CI: 1.00–2.11) were significantly associated with CRC risk. The association was stronger for positivity to two or more pilus proteins of Gallo1569, Gallo2178 and Gallo2179 (OR:1.93, 95% CI: 1.04–3.56) and for double‐positivity to Gallo2178 and Gallo2179 (OR: 3.54, 95% CI: 1.49–8.44). The association between SGG infection and CRC risk was stronger among individuals younger than 65 years. For the first time we demonstrated a statistically significant association of exposure to SGG antigens and CRC in a large seroepidemiological study. These results should stimulate further studies on the role of SGG in CRC pathogenesis.