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Platelets in cancer metastasis: To help the “villain” to do evil
Author(s) -
Li Nailin
Publication year - 2015
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29847
Subject(s) - cancer , cancer cell , metastasis , platelet , cancer research , angiogenesis , medicine , extravasation , immunology
Cancer progress is accompanied by platelet activation and thrombotic complications. Platelets are a dangerous alliance of cancer cells, and are a close engager in multiple processes of cancer metastasis. Platelet adhesion to cancer cells forms a protective cloak that helps cancer cells to escape immune surveillance and natural killer cell‐mediated cytolysis. Platelets facilitate tethering and arrest of disseminated cancer cells in the vasculature, enhance invasive potentials and thus extravasation of cancer cells. Moreover, platelets recruit monocytes and granulocytes to the sites of cancer cell arrest, and collaborate with them to establish a pro‐metastatic microenvironment and metastatic niches. Platelets also secret a number of growth factors to stimulate cancer cell proliferation, release various angiogenic regulators to regulate tumor angiogenesis and subsequently promote cancer growth and progress. Albeit platelets are helping the “villain” cancer to do evil, the close engagements of platelets in cancer metastasis and progress can be used as the intervention targets for new anti‐cancer therapeutic developments. Platelet‐targeted anti‐cancer strategy may bring in novel anti‐cancer treatments that can synergize the therapeutic effects of chemotherapies and surgical treatments of cancer.