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Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium
Author(s) -
Bailey Helen D.,
InfanteRivard Claire,
Metayer Catherine,
Clavel Jacqueline,
Lightfoot Tracy,
Kaatsch Peter,
Roman Eve,
Magnani Corrado,
Spector Logan G.,
Th. Petridou Eleni,
Milne Elizabeth,
Dockerty John D.,
Miligi Lucia,
Armstrong Bruce K.,
Rudant Jérémie,
Fritschi Lin,
Simpson Jill,
Zhang Luoping,
Rondelli Roberto,
Baka Margarita,
Orsi Laurent,
Moschovi Maria,
Kang Alice Y.,
Schüz Joachim
Publication year - 2015
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29631
Subject(s) - childhood leukemia , medicine , odds ratio , recall bias , confidence interval , leukemia , case control study , myeloid leukemia , logistic regression , pesticide , pregnancy , pediatrics , lymphoblastic leukemia , pathology , biology , genetics , agronomy
Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case–control studies in the Childhood Leukemia International Consortium. Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with any pesticide exposure shortly before conception, during pregnancy and after birth were 1.39 (95% confidence interval [CI]: 1.25, 1.55) (using 2,785 cases and 3,635 controls), 1.43 (95% CI: 1.32, 1.54) (5,055 cases and 7,370 controls) and 1.36 (95% CI: 1.23, 1.51) (4,162 cases and 5,179 controls), respectively. Corresponding ORs for risk of acute myeloid leukemia (AML) were 1.49 (95% CI: 1.02, 2.16) (173 cases and 1,789 controls), 1.55 (95% CI: 1.21, 1.99) (344 cases and 4,666 controls) and 1.08 (95% CI: 0.76, 1.53) (198 cases and 2,655 controls), respectively. There was little difference by type of pesticide used. The relative similarity in ORs between leukemia types, time periods and pesticide types may be explained by similar exposure patterns and effects across the time periods in ALL and AML, participants' exposure to multiple pesticides, or recall bias. Although some recall bias is likely, until a better study design can be found to investigate the associations between home pesticide use and childhood leukemia in an equally large sample, it would appear prudent to limit the use of home pesticides before and during pregnancy, and during childhood.

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