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Innate lymphoid cells involve in tumorigenesis
Author(s) -
Tian Zhiqiang,
van Velkinburgh Jennifer C,
Wu Yuzhang,
Ni Bing
Publication year - 2015
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29443
Subject(s) - innate lymphoid cell , biology , carcinogenesis , immunology , immune system , immunity , function (biology) , innate immune system , cytokine , lymphatic system , microbiology and biotechnology , cancer , genetics
Innate lymphoid cells (ILCs) promptly initiate cytokine responses to pathogen exposure in the mucosa and mucosal‐associated lymphoid tissues. ILCs were recently categorized as being of the lymphoid lineage and have been classified into three groups. ILCs play important roles in immunity against pathogens, and an anti‐tumor immune‐related function was recently demonstrated. In this review we discuss whether and how ILCs involve in the tumorigenesis, providing new insights into the mechanisms underlying the particular functions of ILCs as well as the potential targets for tumor intervention.