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Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment
Author(s) -
Penfornis Patrice,
Vallabhaneni Krishna C.,
Whitt Jason,
Pochampally Radhika
Publication year - 2015
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29417
Subject(s) - microvesicles , extracellular vesicles , stromal cell , microrna , tumor microenvironment , carcinogenesis , microbiology and biotechnology , extracellular vesicle , biology , cell , nucleic acid , extracellular , tumor cells , cancer , computational biology , cancer research , biochemistry , genetics , gene
In recent years, the knowledge about the control of tumor microenvironment has increased and emerged as an important player in tumorigenesis. The role of normal stromal cells in the tumor initiation and progression has brought our vision in to the forefront of cell‐to‐cell communication. In this review, we focus on the mechanism of communication between stromal and tumor cells, which is based on the exchange of extracellular vesicles (EVs). We describe several, evergrowing, pieces of evidence that EVs transfer messages through their miRNA, lipid, protein and nucleic acid contents. A better understanding of this sophisticated method of communication between normal cancer cells may lead to developing novel approaches for personalized diagnostics and therapeutics.