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A high and increasing HPV prevalence in tonsillar cancers in E astern D enmark, 2000–2010: The largest registry‐based study to date
Author(s) -
Garnaes Emilie,
Kiss Katalin,
Andersen Luise,
Therkildsen Marianne H.,
Franzmann Maria B.,
FiltenborgBarnkob Bettina,
Hoegdall Estrid,
Krenk Lene,
Josiassen Michael,
Lajer Christel B.,
Specht Lena,
Frederiksen Kirsten,
FriisHansen Lennart,
Nielsen Finn C.,
Kjaer Susanne K.,
Norrild Bodil,
von Buchwald Christian
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29254
Subject(s) - incidence (geometry) , medicine , danish , human papillomavirus , cancer , cancer registry , oncology , gynecology , demography , gastroenterology , philosophy , linguistics , physics , sociology , optics
The aim was to explore whether the incidence of tonsillar squamous cell carcinomas (TSCCs) increased in Eastern Denmark, 2000–2010, and whether human papillomavirus (HPV) could explain the increase, and to assess the association of HPV prevalence with gender, age, and origin ( i.e ., the certainty of tonsillar tumor origin). We applied HPV DNA PCR and p16 immunohistochemistry to all TSCCs registered in the Danish Head and Neck Cancer Group (DAHANCA) and in the Danish Pathology Data Bank ( n = 632). Pathologists reviewed and subdivided the tumors into two groups: specified and nonspecified TSCCs. Approximately 10% of HPV‐positive tumors was genotyped by amplicon next‐generation sequencing. The overall crude incidence of TSCCs increased significantly (2.7% per year) and was explained by an increasing incidence of HPV‐positive TSCCs (4.9% per year). The overall HPV prevalence was 58%, with HPV16 being the predominant HPV type. In multivariate analysis, the HPV prevalence was associated with age (<55 vs . >60 years) (OR, 1.72; 95% CI 1.13–2.63) and origin (nonspecified vs . specified TSCCs) (OR, 0.15; 95% CI 0.11–0.22). The association of HPV prevalence with origin increased over time in specified TSCCs (OR per year, 1.10; 95% CI 1.01–1.19), whereas no change over time was observed among nonspecified TSCCs (OR per year, 0.99; 95% CI 0.90–1.08). In conclusion, the observed increase in the number of HPV‐positive TSCCs can explain the increasing number of TSCCs in Eastern Denmark, 2000–2010. HPV prevalence was associated with younger age (<55 years) and a high certainty of tonsillar tumor origin.