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Meat and fish consumption and the risk of renal cell carcinoma in the E uropean prospective investigation into cancer and nutrition
Author(s) -
Rohrmann Sabine,
Linseisen Jakob,
Overvad Kim,
Lund Würtz Anne Mette,
Roswall Nina,
Tjonneland Anne,
BoutronRuault MarieChristine,
Racine Antoine,
Bastide Nadia,
Palli Domenico,
Agnoli Claudia,
Panico Salvatore,
Tumino Rosario,
Sacerdote Carlotta,
Weikert Steffen,
Steffen Annika,
Kühn Tilman,
Li Kuanrong,
Khaw KayTee,
Wareham Nicholas J.,
Bradbury Kathryn E.,
Peppa Eleni,
Trichopoulou Antonia,
Trichopoulos Dimitrios,
BuenodeMesquita H.Bas,
Peeters Petra H.M.,
Hjartåker Anette,
Skeie Guri,
Weiderpass Elisabete,
Jakszyn Paula,
Dorronsoro Miren,
Barricarte Aurelio,
Santiuste de Pablos Carmen,
MolinaMontes Esther,
de la Torre Ramón Alonso,
Ericson Ulrika,
Sonestedt Emily,
Johansson Mattias,
Ljungberg Börje,
Freisling Heinz,
Romieu Isabelle,
Cross Amanda J.,
Vergnaud AnneClaire,
Riboli Elio,
Boeing Heiner
Publication year - 2014
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.29236
Subject(s) - european prospective investigation into cancer and nutrition , hazard ratio , medicine , incidence (geometry) , prospective cohort study , renal cell carcinoma , proportional hazards model , red meat , cancer , lower risk , confidence interval , kidney cancer , epic , cancer prevention , pathology , art , physics , literature , optics
Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 and 2000. Until December 2008, 691 RCC cases have been identified. Meat and fish consumption was assessed at baseline using country‐specific dietary assessment instruments; 24‐hour recalls were applied in an 8% subsample for calibration purposes. Cox proportional hazards regression was used to calculate multivariable‐adjusted hazard ratios (HR) and 95% confidence intervals (CI). Women with a high consumption of red meat (HR = 1.36, 95% CI 1.14–1.62; calibrated, per 50 g/day) and processed meat (HR = 1.78, 95% CI 1.05–3.03; calibrated, per 50 g/day) had a higher risk of RCC, while no association existed in men. For processed meat, the association with RCC incidence was prominent in premenopausal women and was lacking in postmenopausal women ( p interaction = 0.02). Neither poultry nor fish consumption were statistically significantly associated with the risk of RCC. The results show a distinct association of red and processed meat consumption with incident RCC in women but not in men. A biological explanation for these findings remains unclear.