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Microsatellite instability in oral cancer
Author(s) -
Ishwad Chandramohan S.,
Ferrell Robert E.,
Rossie Karch M.,
Appel Billy N.,
Johnson Jonas T.,
Myers Eugene N.,
Law John C.,
Srivastava S.,
Gollin Susanne M.
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910640509
Subject(s) - microsatellite instability , genome instability , dna mismatch repair , microsatellite , biology , allele , germline mutation , genetics , colorectal cancer , somatic cell , cancer , germline , cancer research , mutation , dna , gene , dna damage
Generalized genomic instability, detected as somatic changes in allele sizes at microsatellite loci in tumors compared to peripheral lymphocyte DNA, is a recently recognized mechanism of mutation in cancer. Such instability results from the Somatic loss of DNA mismatch repair capability. Germ‐line mutations at DNA mismatch repair loci confer susceptibility to colon cancer in hereditary non‐polyposis colorectal cancer. Somatic loss of DNA mismatch repair has been reported in a large variety of other tumor types. Our goal was to determine the frequency of microsatellite instability in a large series of oral tumors. Out of 91 tumors analyzed for microsatellite instability, 6 (7%) showed microsatellite instability. Instability was observed at multiple loci with a range of 50‐74% of loci affected. Alterations include both increase (74%) and decrease (26%) in allele sizes. The proportion of alleles affected ranged from 30‐58% of all alleles. Our data suggest that somatic genomic instability plays a role in the pathogenesis of a small subset of oral tumors. © 1995 Wiley‐Liss, Inc.