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The essential role of endogenous IFN α/β in the anti‐metastatic action of sensitized T lymphocytes in mice injected with friend erythroleukemia cells
Author(s) -
Gresser Ion,
Maury Chantal,
Kaido Thomas,
Bandu MarieThérèse,
Tovey Michael G.,
Maunoury MarieThérèse,
Fantuzzi Laura,
Gessani Sandra,
Greco Giampaolo,
Belardelli Filippo
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910630520
Subject(s) - endogeny , spleen , immune system , adoptive cell transfer , immunology , beta (programming language) , ratón , antibody , alpha (finance) , t lymphocyte , biology , t cell , medicine , endocrinology , construct validity , nursing , patient satisfaction , computer science , programming language
Abstract Adoptive transfer of splenic T lymphocytes from DBA/2 mice immunized against Friend erythroleukemia cells (FLC) inhibited the development of visceral metastases and increased the survival time of DBA/2 mice challenged i.v. with parental FLC 24 hr to 2 months later. Immune spleen cells were ineffective in mice pre‐treated with potent neutralizing antibody to mouse IFN α/β (but not to IFN γ), demonstrating the essential participation of endogenous IFN α/β in the inhibitory action of immune T lymphocytes against FLC metastases. These findings suggest that the reported inability of immune T lymphocytes to exert an anti‐FLC effect in immunodeficient DBA/2 mutant beige ( bg/bg ) mice (unless these mice had also been treated with IFN α/β), may have been due to lower levels of endogenous IFN α/β in DBA/2 bg/bg mice than in normal DBA/2 +/ bg mice. Experimental results in support of this hypothesis are presented. © 1995 Wiley‐Liss, Inc .