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Trisomy 20 is a primary chromosome aberration in desmoid tumors
Author(s) -
Mertens Fredrik,
Willén Helena,
Rydholm Anders,
Brosjö Otte,
Carlén Birgitta,
Mitelman Felix,
Mandahl Nils
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910630412
Subject(s) - trisomy , supernumerary , biology , chromosome , pathology , aneuploidy , karyotype , chromosome aberration , autosome , marker chromosome , genetics , medicine , anatomy , gene
Chdtogenetic analysis revealed trisomy 20 in 4 desmoid tumors: in 2 cases as the sole aberration, in hd together with +X, ‐Y and −13 and in I with +8 and a supernumerary marker chromosome. Our findings indicate that gain of chromosome 20 is an early event in the development of a large subset of desmoid tumors and that it is as frequent as +8, the only consistent chromosomal change previously reported in this tumor type. The non‐random occurrence of trisomies 8 and 20 in desmoid tumors indicates shared pathogenetic mechanisms with infantile fibrosarcoma, a fibrous tissue tumor characterized by various combinations of trisomies for chromosomes 8, 11, 17 and 20.