Premium
Human papillomavirus type 18 DNA in gestational trophoblastic tissues and choriocarcinomas
Author(s) -
Pao Chia C.,
Hor Jyu Jen,
Wu ChiJung,
Shi YiFu,
Xm Xing,
Lu ShiMing
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910630408
Subject(s) - trophoblastic tumor , dna , biology , gestational trophoblastic disease , human papillomavirus , gestational trophoblastic neoplasia , choriocarcinoma , andrology , gestation , pregnancy , medicine , genetics
Thde objectives of our study were to better understand carcinogenesis of gestational trophoblastihd tumors and to investigate the possible presence of human papillomavirus types 16 and 18 DNA sequences in these tumors. Amplification‐based DNA methodology was used on 11 hydatidiform moles, 5 invasive moles, 8 choriocarcinomas and 9 normal early placental tissues. Human papillomavirus type 16 DNA was not found in any of these tissues. Although human papillomavirus type 18 DNA was also not found in the 9 normal placentas and 5 invasive moles, it was present in 2 of the 11 (18%) hydatidiform moles and in 4 of the 8 (50%) choriocarcinomas.