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Decreased biotolerability for ivermectin and cyclosporin a in mice exposed to potent P‐glycoprotein inhibitors
Author(s) -
Didier Agnès D.,
Loor Francis
Publication year - 1995
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910630220
Subject(s) - ivermectin , p glycoprotein , glycoprotein , pharmacology , ratón , medicine , biology , immunology , microbiology and biotechnology , biochemistry , antibiotics , veterinary medicine , multiple drug resistance
SDZ PSC 833 or SDZ 280‐446 are strong blockers of the function of class 1 mdr gene‐encoded P‐glycoprotein molecules, which were developed for the reversal of multi‐drug‐resistance of tumor cells. When treated with such drugs, normal mice may display hypersensitivity to cyclosporin A and ivermectin. The recorded signs of acute toxicity are compatible with alterations of the murine central nervous system functions and with earlier data suggesting that P‐glycoprotein expressed at the murine blood‐brain barrier might be involved in the exclusion of cyclosporin A or ivermectin from brain tissue.